• To directly test the hypothesis

  2020-07-31

  

  To directly test the hypothesis that hepatic steatosis leads to insulin resistance, we studied transgenic mice that overexpress human DGAT enzymes, which catalyze the final step of triacylglycerol (TG) biosynthesis (Buhman et al., 2001), in the liver. We focused on mice overexpressing DGAT2 (Liv-DGA

• Nearly years ago the first two enzymes which

  2020-07-31

  

  Nearly 60years ago, the first two FG2216 receptor which catalyze the phosphorylation of proteins were discovered [1]. Protein phosphorylation was originally identified as a regulatory mechanism for the control of glycogen metabolism. Today it is clear that protein phosphorylation regulates most asp

• Introduction With an annual world

  2020-07-30

  

  Introduction With an annual world production of around 750 million tons, wheat is grown on more agricultural area than any other food crop and is the main source of plant protein in human nutrition [1,2]. Wheat is composed of 8–15% protein, from which 85–90% is gluten [3]. The unique viscoelastic a

• In our previous study it has been shown

  2020-07-30

  

  In our previous study it has been shown that the bis-3-chloropiperidine B3 with a flexible pentyl hydrocarbon linker exhibited highly efficient DNA alkylating activity (see also gel electrophoresis data below, Fig. 2a). The amino Suramin hexasodium salt sale l-lysine 7 is a suitable linker structur

• The outcome of DGK function will thus

  2020-07-30

  

  The outcome of DGK function will thus depend on the binding partners of each DGK isoform, and the effects that they exert can be quite different. A clear example of this concept has been demonstrated for the type IV DGKs, ζ and ι, which are structurally very similar but have opposing effects on Ras

• Therefore P falciparum DHODH PfDHODH represents a target for

  2020-07-30

  

  Therefore, P. falciparum DHODH (PfDHODH) represents a target for the discovery and development of parasite-specific inhibitors that could lead to promising antimalarial lead compounds [18,23]. Different chemical scaffolds have been identified as potent inhibitors of PfDHODH that show strong selectiv

• br Discussion Type I collagen is an important adhesive

  2020-07-30

  

  Discussion Type I collagen is an important adhesive protein for use as scaffolding material for various tissue engineering applications [4], [5]. An understanding of how the various features of collagen matrices influence cell behavior is hence of great current interest [6]. Even for monotypic li

• br Experimental br Results and discussion br Conclusions In

  2020-07-30

  

  Experimental Results and discussion Conclusions In this work we presented the direct electrochemical behaviour of the Mo containing formate dehydrogenase, purified from D. desulfuricans, where the Mo centre redox features were observed. The results allowed to calculate the reduction potenti

• The pathogenesis of pulmonary fibrosis involves alveolar epi

  2020-07-30

  

  The pathogenesis of pulmonary fibrosis involves alveolar epithelial cell injury, inflammatory cell infiltration, as well as fibroblast recruitment and activation. It has been long accepted that the activated fibroblasts (so-called myofibroblasts), characterized by de novo expression of α-smooth musc

• The in vitro studies support our previous observations of a

  2020-07-30

  

  The in vitro studies support our previous observations of a bimodal expression pattern of B. malayi transcripts after tetracycline treatment, including the two enzymes we studied here. We hypothesize that this bimodal expression may be due to stage-specific responses of the host in response to Wolba

• When D structure of the macromolecular target is not availab

  2020-07-30

  

  When 3D structure of the macromolecular target is not available 3D-QSAR is the prominent computational means to support chemistry within drug design projects (Puzyn et al., 2010). The primary objective of 3D QSAR was to understand which properties are important to control a specific biological activ

• br A summary of CRM structures Many crystal structures of

  2020-07-30

  

  A summary of CRM1 structures Many crystal structures of CRM1 have been published in the last five years. 27 CRM1 structures are now available in the PDB [64]. CRM1 from several organisms (human, mouse, fungi Chaetomium thermophilum and Saccharomyces cerevisiae) were used in these studies but CRM1

• Another option is to use the thiol groups of

  2020-07-30

  

  Another option is to use the thiol groups of cysteine residues, which can be modified by use of PEG-maleimide and vinyl sulfone. However, changes in PEGylation interactions or reaction conditions can result in changes in the functional properties of the therapeutic proteins [[50], [51], [52]]. A s

• Models and theories The CPA

  2020-07-30

  

  Models and theories The CPA equation of state is composed predominantly of two parts: physical item and the association item based on the thermodynamic perturbation theory [21], [22], [26], [27]. The physical item is used to represent intermolecular physical interaction, usually representing the SR

• Understanding the nature of protein collagen

  2020-07-29

  

  Understanding the nature of protein–collagen interactions is also crucial in developing biomaterials that replicate the structural and biological characteristics of collagen [140]. These biomaterials can then be applied to develop scaffolds or tissues that can be valuable in surgeries or medicine [7

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