• The pathogenesis of pulmonary fibrosis involves alveolar epi

  2020-07-30

  

  The pathogenesis of pulmonary fibrosis involves alveolar epithelial cell injury, inflammatory cell infiltration, as well as fibroblast recruitment and activation. It has been long accepted that the activated fibroblasts (so-called myofibroblasts), characterized by de novo expression of α-smooth musc

• The in vitro studies support our previous observations of a

  2020-07-30

  

  The in vitro studies support our previous observations of a bimodal expression pattern of B. malayi transcripts after tetracycline treatment, including the two enzymes we studied here. We hypothesize that this bimodal expression may be due to stage-specific responses of the host in response to Wolba

• When D structure of the macromolecular target is not availab

  2020-07-30

  

  When 3D structure of the macromolecular target is not available 3D-QSAR is the prominent computational means to support chemistry within drug design projects (Puzyn et al., 2010). The primary objective of 3D QSAR was to understand which properties are important to control a specific biological activ

• br A summary of CRM structures Many crystal structures of

  2020-07-30

  

  A summary of CRM1 structures Many crystal structures of CRM1 have been published in the last five years. 27 CRM1 structures are now available in the PDB [64]. CRM1 from several organisms (human, mouse, fungi Chaetomium thermophilum and Saccharomyces cerevisiae) were used in these studies but CRM1

• Another option is to use the thiol groups of

  2020-07-30

  

  Another option is to use the thiol groups of cysteine residues, which can be modified by use of PEG-maleimide and vinyl sulfone. However, changes in PEGylation interactions or reaction conditions can result in changes in the functional properties of the therapeutic proteins [[50], [51], [52]]. A s

• Models and theories The CPA

  2020-07-30

  

  Models and theories The CPA equation of state is composed predominantly of two parts: physical item and the association item based on the thermodynamic perturbation theory [21], [22], [26], [27]. The physical item is used to represent intermolecular physical interaction, usually representing the SR

• Understanding the nature of protein collagen

  2020-07-29

  

  Understanding the nature of protein–collagen interactions is also crucial in developing biomaterials that replicate the structural and biological characteristics of collagen [140]. These biomaterials can then be applied to develop scaffolds or tissues that can be valuable in surgeries or medicine [7

• Here we show that DDR protein is

  2020-07-29

  

  Here, we show that DDR2 protein is concordantly upregulated in MSCs and cancer Fumonisin B1 synthesis in clinical samples of human breast cancer metastasis to several organs. DDR2 expression in MSCs derived from breast cancer metastasis (Met-MSCs) regulates stromal phenotype and function and mediat

• br Conclusion S chirata and ursolic acid showed very

  2020-07-29

  

  Conclusion S. chirata and ursolic AT7867 showed very less inhibition on both CYP3A4 and CYP2D6 isozymes which was insignificant as compared to their known inhibitors (ketoconazole and quinidine). The tested heavy metals and trace elements present in S. chirata were within the prescribed limit. T

• br Introduction Human urocortin II hUcn II

  2020-07-29

  

  Introduction Human urocortin II (hUcn II, also known as stresscopin-related peptide) and urocortin III (hUcn III also known as stresscopin) are novel members of the corticotropin-releasing factor (CRF) family that have been recently identified from the human genome data ciprofloxacin and from ho

• dofetilide In rats exposed to day of nicotine

  2020-07-29

  

  In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w

• Carbon dioxide is the gas most commonly applied

  2020-07-29

  

  Carbon dioxide is the gas most commonly applied for supercritical fluid extraction due to its low cost, high purity, safety and low critical properties. Since pure supercritical carbon dioxide (scCO2) is a lipophilic solvent, mixtures with organic solvents, especially alcohols, are used to increase

• atp citrate lyase inhibitor br Experimental Procedures br Au

  2020-07-28

  

  Experimental Procedures Author Contributions Acknowledgments We thank Laurentino Villar for protein purifications, Dr. Miguel de Vega for valuable suggestions and critical reading of the manuscript, and Professor Luis Blanco for helpful discussions and the [γ-32P]ATP-(dGMP)n ladder. M.S.’s

• br Introduction Cardiovascular disease continues

  2020-07-28

  

  Introduction Cardiovascular disease continues to be the leading cause of death in developed countries. Atherosclerosis, a chronic inflammatory cardiovascular disease, is characterized by the progressive buildup of oxidized low density lipoproteins in the arterial walls (Ross, 1999). In the develo

• Corticosteroids and adrenergic receptor agonists

  2020-07-28

  

  Corticosteroids and adrenergic β2 receptor agonists have been clinically used as effective pharmacotherapy for asthma. In this study, asthmatic response in both S-hexyl GSH-non-treated and treated animals was attenuated by single treatment with dexamethasone or salmeterol. Combination treatment with

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