• Although the control group and tinnitus group do not signifi

  2021-02-09

  

  Although the control group and tinnitus group do not significantly differ based on age, gender or hearing loss, a limitation of this study is that the control group is only group-matched, and not individually matched. Furthermore, we only tested hearing acuity in tinnitus patients via standard pure

• Does hydroxylation of proline have

  2021-02-09

  

  Does hydroxylation of proline have a specific role in the structure and function of the conotoxins? Several studies in the literature provide insights into the role of proline hydroxylation in the Conus peptides. The consequences of proline hydroxylation on oxidative folding and biological activity

• br Materials and methods br Results To

  2021-02-09

  

  Materials and methods Results To investigate the effect of 17βE on cell proliferation in the human renal tubular epithelia, BrdU uptake was measured in HRTEC primary and 3D-HRTEC cultures, allowing determination of the DNA replication rate. Representative microphotographs show BrdU uptake in H

• Astrocytes play a key role in

  2021-02-09

  

  Astrocytes play a key role in the brain, as these cells are involved in fluid, ion, pH, and neurotransmitter homeostasis, synapse function, energy and metabolism and blood-brain barrier (BBB) maintenance (Sofroniew and Vinters, 2010). PA is able to activate different damaging responses in astrocytes

• br Conflict of interest statement br References and recommen

  2021-02-09

  

  Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We acknowledge financial support by the Swiss State Secretariat for Education, Research and Innovation (Federal

• In human neuroblastoma SH SY Y cells

  2021-02-09

  

  In human neuroblastoma SH-SY5Y Plumbagin and in lymphoma Jurkat cells, Yamanaka et al. [56] showed that exogenously added 24(S)-hydroxycholesterol could be efficiently esterified by ACAT1. These results suggest that both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying them,

• CYP A and CYP D are among

  2021-02-09

  

  CYP3A4/5 and CYP2D6 are among the main drug-metabolizing enzymes in humans that are responsible for the metabolism of more than 50% of marketed drugs [19], [21]. Drugs metabolized by CYPs are prone to drug–drug interactions, thereby modifying their response [18], [32]. Metabolic inhibition is also i

• HOAt br Results and Discussion br Conclusions Understanding

  2021-02-09

  

  Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes

• Several DA receptors heteromers with a therapeutic potential

  2021-02-09

  

  Several DA receptors heteromers with a therapeutic potential have been described, including D1R/D3R (Fiorentini et al., 2010), but their roles remain to be established. Moreover, most studies on receptor heteromers in addiction focused on the striatum because of its key role in the pathology and its

• Until recently the first line treatment of RLS was the

  2021-02-09

  

  Until recently, the first line treatment of RLS was the administration of low dose of three dopaminergic drugs, which has been approved by the US Food and Drug Administration and the European Medicines Agency for the treatment of moderate to severe RLS. These compounds are pramipexole (Mirapex), rop

• HPF australia Introduction The carnitine choline acyltransfe

  2021-02-08

  

  Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) HPF australia and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of

• Not all of the biological

  2021-02-08

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the T0901317 receptor is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to r

• In rodent models the loss of estrogens through

  2021-02-08

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an Sulfamethazine receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthas

• br Disclosures br Acknowledgements This work

  2021-02-08

  

  Disclosures Acknowledgements This work was supported in part by grants from the Ministerio de Ciencia e Innovación, Spain (SAF2010-22051) and Xunta de Galicia, Spain (INCITE08PXIB203092PR). Introduction Ca is a key element in cardiac excitation–contraction (EC) coupling. In each heartbeat,

• In conclusion we for the

  2021-02-08

  

  In conclusion, we for the first time demonstrated the enzyme activity and immunoprotective traits of bioactive recombinant SjCE-2b, which was successfully recovered by protein refolding from inclusion bodies. The results address two essential questions that were undocumented in previous investigatio

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