• br Materials and methods br Results br Discussion

  2021-12-22

  

  Materials and methods Results Discussion An HMC is a blinding type of cataract frequently observed in Asian countries due to the appallingly high incidence of high myopia in those areas [4], [5] and typically features earlier onset and more rapid progression of nuclear cataract [1], [2]. Th

• In our studies the EC values for long chain unsaturated

  2021-12-22

  

  In our studies, the EC50 values for long-chain unsaturated fatty acids added to the short form of human GPR120 receptor (BC101175), were higher than the EC50 values previously reported (Hirasawa et al., 2005) for the long form of GPR120 (NM_181745), which was co-expressed with Gα16 protein.(Table 2)

• Based on the results of

  2021-12-22

  

  Based on the results of , i thought about this appeared to have the best overall profile, so our efforts were then devoted to using 5-(-propyl)pyrimidine as the right-hand nitrogen attachment to optimize the R group of (). Analog was synthesized using the reaction conditions from , while analogs

• Originally identified as a GPCR upregulated on Burkitt lymph

  2021-12-22

  

  Originally identified as a GPCR upregulated on Burkitt lymphoma cells upon Epstein-Barr virus infection (Birkenbach et al., 1993), Ebi2 was later found to play critical roles in immunity by regulating the migration of activated honokiol to extrafollicular sites for early plasmablast responses (Gatt

• br Materials animals and methods br Results

  2021-12-22

  

  Materials, animals and methods Results Discussion This study presents mice with a missense point mutation in R258 of FFAR1 that has functional consequences. Firstly, in islets of Ffar1R258W/R258W mice, both the physiological agonist palmitate and the synthetic agonist TUG-469 were unable to

• br Conclusions There are a number of factors that

  2021-12-22

  

  Conclusions There are a number of factors that affect the transit of solutes through gap junction channels. Fig. 4 provides a simplified illustration of those factors. First is the cytoplasmic vestibule through which all permeable solutes must pass to gain access to the pore. In an equivalent cir

• DNAzymes a series of nucleotide sequences

  2021-12-22

  

  DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN

• In summary PPARG and FFAR are connected in

  2021-12-22

  

  In summary, PPARG and FFAR1 are connected in several ways, and the presented interaction is mechanistically reasonable. Additional investigations are required to elucidate the exact details of the underlying physiology. However, our findings are of immanent importance for the treatment of type 2 dia

• To identify genes with significant expression differences

  2021-12-21

  

  To identify genes with significant lb100 receptor differences, we performed differential gene expression analysis between the two individuals with TRRAP variants (combined as biological replicates) and two unaffected controls. Gene ontology (GO) enrichment analysis of these genes with the GOrilla w

• CD CD belong to the costimulatory adhesion

  2021-12-21

  

  CD80/CD86 belong to the costimulatory adhesion molecule family, which can activate T BCECF-AM by the costimulatory pathway and have been used as indicators of DC maturation in numerous studies. In addition, MHC-II, as the principal component of antigen presentation, was significantly elevated after

• The selection of mutations in vivo with antivirals is

  2021-12-21

  

  The selection of mutations in vivo with antivirals is a complex process involving, among other things, the frequency of a given mutation prior to treatment, the effect of that mutation on viral protein function, and the interplay of a given mutation pattern with host immune mechanisms. Investigatio

• PBI is an agonist of GPR and acts as

  2021-12-21

  

  PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th

• br Activity dependent control of myelination and

  2021-12-21

  

  Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed Anisomycin in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or other cells in

• br Discussion The Pro Ala variant

  2021-12-21

  

  Discussion The Pro12Ala variant in PPARG has been one of the first candidate SNPs for type 2 diabetes [16], [17]. The rare allele of this variant is associated with a 25% reduced risk for the disease [18]. Given the role of PPARG as both a receptor for NEFA and itself a regulator of fat metabolis

• br Conclusion In summary a series of

  2021-12-21

  

  Conclusion In summary, a series of novel GPR40 agonists bearing phenylpropiolic e1 activating enzyme motif with favorable metabolic stability were prepared and evaluated for their activities as GPR40 agonists. Among them, compound 9 was identified as a structurally distinct GPR40 agonist possess

16207 records 541/1081 page Previous Next First page 上5页 541542543544545 下5页 Last page