• Dopaminergic neurons are vulnerable to oxidative products an

  2024-10-12

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial TRAM 39 are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dysfunction must

• br Materials and methods br Results br

  2024-10-12

  

  Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include colorimetric assay synthesis proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and coll

• br STAR Methods br AMPK A

  2024-10-11

  

  STAR★Methods AMPK: A Therapeutic Target in the β Cell? Loss of pancreatic β cell function is a hallmark of the transition to a diagnosis of T2DM (see Glossary) 1, 2, 3, 4. AMPK activation has gained attention for the treatment of hyperglycemia in prediabetes as an insulin-sensitizing agent bec

• We find that the interaction of NSF and SNAP

  2024-10-11

  

  We find that the interaction of NSF and SNAP is critically involved in NMDAR-induced PICK1 unclustering. The binding of SNAP to NSF increases the ATPase activity of NSF, which is known to be essential for the unbinding of PICK1 from GluR2 (Hanley et al., 2002). Disruption of the association between

• Evidence shows that glial activation increases the expressio

  2024-10-11

  

  Evidence shows that glial activation increases the expression of cytokines and chemokines in Parkinson's disease, which precede the degeneration of the substance nigra (Halliday and Stevens, 2011, Tansey and Goldberg, 2010). The use of non-steroidal anti-inflammatory drugs (except aspirin) can preve

• br Perspectives br Acknowledgments This investigation was su

  2024-10-11

  

  Perspectives Acknowledgments This investigation was supported by a Research Grant 2010/01385-5 from FAPESP (Sao Paulo Research Foundation, Brazil). P.F.S. was recipient of a CNPq (National Council for Scientific and Technological Development, Brazil) productivity grant. R.F.A. was recipient of

• br Conflict of interest statement br Introduction Currently

  2024-10-11

  

  Conflict of interest statement Introduction Currently, adenocarcinoma is the most common histological subtype of lung cancer. Activating mutations and translocations with a potential for targeted therapy are reported predominantly in non-smokers. ALK rearrangement is found in less than 5% of u

• br Aldehyde sensors to monitor substrate levels Previous

  2024-10-11

  

  Aldehyde sensors to monitor substrate levels Previous efforts to ameliorate metabolic diseases frequently relied on biochemical methods which could measure the levels of toxic substrates in Cy5.5 carboxylic acid (non-sulfonated) or bodily fluids (blood and serum or plasma, urine, cerebrospinal f

• Most of the modifications in the sympathetic nervous system

  2024-10-11

  

  Most of the modifications in the sympathetic nervous system occurring with aging, including decreased βAR responsiveness, increased circulating catecholamines, and overall hyposensitivity to adrenergic stress, are also observed in patients with failing hearts. Moreover, young people are more reactiv

• br Methods br Results br Discussion Adiponectin is naturally

  2024-10-11

  

  Methods Results Discussion Adiponectin is naturally expressed and secreted exclusively from adipocytes, and adiponectin levels and its isoforms in circulation have recently been reported to highly associate with human coronary artery disease (CAD) [46], [47], [48], [49], these studies clear

• Changes in actin microfilaments are mediated

  2024-10-11

  

  Changes in SB 203580 microfilaments are mediated by changes in extracellular matrix, mechanical stimulation or growth factors intracellular signaling. We observed significant changes in a number of intracellular signaling pathways associated with changes in actin dynamics during hMSCs differentiati

• Tension within the network could be explained by

  2024-10-11

  

  Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling MK-0518 filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filaments [2].

• Stroke also known as a cerebrovascular

  2024-10-11

  

  Stroke, also known as a cerebrovascular accident or Ciprofibrate attack, is one of the leading causes of death and disability worldwide (Haley et al., 2017; Hankey, 2017; Lie et al., 2017). According to the data released by the World Health Organization (WHO), stroke occurs every 5 s worldwide (WHO

• br Dysregulated aromatase expression the link between obesit

  2024-10-10

  

  Dysregulated aromatase expression: the link between obesity and breast cancer Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, influencing the local production and bioavailability of estrogens (Morris et al, 2011, Subbaramaiah et al, 2012). Bowers

• br Discussion Arginase and Arginase are homologous enzymes

  2024-10-10

  

  Discussion Arginase 1 and Arginase 2 are homologous enzymes that consume l-arginine to produce l-ornithine and urea [14], [15]. These enzymes compete with NO synthases for the same substrate [14], [15], [30], and therefore may reduce NO production [21], [24], [30]. The colocalization of arginases

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