• Multi electrode array approaches have been proposed as a too

  2018-11-08

  

  Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure

• br Results br Discussion Analysis of DNA damage

  2018-11-08

  

  Results Discussion Analysis of DNA-damage foci in CHK1i-treated EMD638683 led to the remarkable discovery that CHK1i allowed FA-deficient iPSCs to escape G2 arrest and undergo mitosis without repairing the DSBs that had evidently caused their arrest. A previous study indicates that DSBs arisi

• The present study indicated that induction of glutamatergic

  2018-11-08

  

  The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced vG

• br Ethics approval br Acknowledgments br Introduction Low so

  2018-11-07

  

  Ethics approval Acknowledgments Introduction Low socioeconomic status (SES) is frequently found to be associated with poor health outcomes, despite substantial advances in prevention and treatment of disease (Phelan & Link, 2005; Braveman, Cubbin, Marchi, Egerter, & Chavez, 2001; Janssen, B

• Hence Hulme and Shepherd aware

  2018-11-07

  

  Hence, Hulme and Shepherd (2003), aware of the need to distinguish the different forms of poverty, define five groups, according to the location of poverty\'s punctual and average indicators vis-à-vis the poverty line. This paper seeks to adapt such typology to Brazil\'s case, using PME (Monthly Job

• The development of a malaria vaccine is considered

  2018-11-07

  

  The development of a malaria vaccine is considered as one of the most cost-effective measures to counter the disease. Valuable progress has been achieved in the last 30years in the development of subunit vaccines () that could be included in the Expanded Program of Immunization (EPI), whereas the

• Worry about the next night s

  2018-11-07

  

  Worry about the next night\'s insomnia was an important part of the routine. The finding suggests that in addition to the experience of insomnia, these patients worry about being an insomniac. The issue explains a state similar to anticipatory anxiety in panic disorders in which a patient experience

• br Conclusiones br Introducci n br I

  2018-11-07

  

  Conclusiones Introducción I. El entorno económico y financiero mundial El entorno monetario y financiero mundial se encuentra en un proceso continuo de transformación y ajuste. El cual es el producto de un entorno conflictivo de juego suma cero en el que un país gana lo que otro pierde, por

• Increasing globalization in travel and trade will intensify

  2018-11-07

  

  Increasing globalization in travel and trade will intensify the importation of dengue viruses and the potential for further introduction of Ae. aegypti (Gubler and Clark, 1995). If such introductions coincide with suitable vectorial capacity, those cities at the time intervals identified in this stu

• Interestingly SR had an anabolic effect

  2018-11-07

  

  Interestingly, SR10171 had an anabolic effect on the appendicular but not the axial skeleton, whereas rosiglitazone had a negative effect in both skeletal sites. There are several possible explanations for this divergence. Firstly, osteocytes were shown to be a major anabolic target of SR10171. Thes

• The endocannabinoid system ECS is a recently emerging comple

  2018-11-07

  

  The endocannabinoid system (ECS) is a recently emerging complex regulator of multiple physiological processes. It comprises several endogenous ligands (e.g. -arachidonoylethanolamine, a.k.a. anandamide [AEA], 2-arachidonoylglycerol [2-AG], palmitoylethanolamide [PEA], etc.), a number of endocannabin

• Similar to other solid tumors the characteristics such as

  2018-11-07

  

  Similar to other solid tumors, the characteristics such as tumor size, tumor differentiation, tumor node numbers, vascular invasion, and metastasis status are important prognosis factors for HCC patients (Noh et al., 2016). These characteristics constitute the tumor-node-metastasis (TNM) classificat

• Sialic acid residues might also play a role in another

  2018-11-07

  

  Sialic igf ir residues might also play a role in another way. IgG preparations contain large amounts of sialylated antibodies and recent studies have demonstrated that these are crucial for the anti-inflammatory effects of IVIg [reviewed in ()]. Both the F(ab) part as well as the Fc part of the ant

• br Acknowledgments We thank Sofie Vande Casteele

  2018-11-07

  

  Acknowledgments We thank Sofie Vande Casteele for the assistance with the maintenance of our Waters Premier LC–MS, the platform applied for the development, and optimization of the protocol. We thank Niklaas Colaert for the support with the Rover software and Kristof De Beuf from the FIRE Statist

• Value of the data br Data experimental

  2018-11-07

  

  Value of the data Data, experimental design, materials and methods Acknowledgments This work was financially supported by the grant sponsors: Shenzhen Municipal Committee of Science and Technology Innovation (Grant number: JC201105190969A) and the National Public Sector (AQSIQ) Special Funds

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