• Adult HSCs can be highly

  2018-11-06

  

  Adult HSCs can be highly purified (Purton and Scadden, 2007; Osawa et al., 1996). This is in contrast to the first HSCs found in the embryo, which have been more difficult to enrich thus far (Taoudi et al., 2005). Many markers currently used to isolate adult HSCs do not apply for embryonic HSCs. Mor

• br Acknowledgments br Introduction Mouse embryonic stem ES c

  2018-11-06

  

  Acknowledgments Introduction Mouse embryonic stem (ES) Tunicamycin can give rise to all somatic cell types and germ cells in a regulative manner and are thereby defined as pluripotent. They are thought to have ‘no pre-determined programme’. However, whether or not an ES cell represents a ‘tabu

• To identify a molecular marker that can serve

  2018-11-06

  

  To identify a molecular marker that can serve as an indicator of the differentiaion potential of the cell lines tested, we analyzed the strontium chloride levels of a group of genes in hESCs that include pluripotent transcription factors, modulators of various signaling pathways known to be involve

• br Macrophage roles in cardiac injury responses While cTMs m

  2018-11-06

  

  Macrophage roles in cardiac injury responses While cTMs may play an important role in cardiac homeostasis, they are likely to be amongst the first cell types to react to cardiac tissue damage. Following injury, a robust inflammatory response involves secretion of various cytokines and infiltratio

• In order to determine whether the neonatal

  2018-11-06

  

  In order to determine whether the neonatal mammalian heart harbors any significant regenerative capacity, we recently developed a surgical model of cardiac injury in 1-day-old neonatal mice (Fig. 1) (Porrello et al., 2011a). Following amputation of a portion of the ventricular apex comprising approx

• Here we show that cholesterol metabolites

  2018-11-06

  

  Here, we show that cholesterol metabolites play an important role in cardiac differentiation in mouse embryonic stem cells (mESC). Gcrt receptor expression in the early mouse embryo and its exclusive localization to cell nuclei within the visceral endoderm then prompted us to further investigate a p

• br Materials and methods br Author disclosure statement

  2018-11-06

  

  Materials and methods Author disclosure statement 5. Acknowledgments This work was supported by the UK Medical Research Council grants G0701172 and G0801061. We thank Dr. Yacoub Khalaf, director of the Assisted Conception Unit of Guy\'s and St. Thomas\' NHS Foundation Trust and his staff fo

• Based on the differentiation and siRNA studies reported

  2018-11-06

  

  Based on the differentiation and siRNA studies reported here, the mechanistic regulation of FOXM1 towards pluripotency control and differentiation might differ between mouse and human ES cells. The discrepancy can be attributed to the different developmental status of human versus mouse ES cells (Ni

• The sorted BMSC and HSPC populations were observed

  2018-11-06

  

  The sorted BMSC and HSPC populations were observed to exist in distinct states of the cell cycle, equally important for their functions as stem cells. The MG-132 gene expression studies further ascertained the cellular physiology of both the sorted cell populations. Our results also coincide with s

• br Materials and methods br

  2018-11-06

  

  Materials and methods Results Discussion Others and we have demonstrated that ESC-based developmental modeling mimics a variety of neurodevelopmental events occurring in vivo using either 2-D or 3-D systems. In those studies, the hESC-based developmental model has been proposed to imitate e

• Background green fluorescence was detected in the lentiviral

  2018-11-06

  

  Background green fluorescence was detected in the lentiviral reprogrammed MML-6838-CL2 iPSC line and a control episomal (non-GFP) reprogrammed iPSC, indicating silencing (Fig. 1B). Pluripotency was confirmed by detecting expression of SOX2, OCT4, SSEA4, TRA1-61 and TRA1-80 pluripotency-associated ma

• In summary our results have

  2018-11-05

  

  In summary, our results have shown that Notch signaling could inhibit the expression of miR-342-5p. In NSCs where Notch signaling is activated, the level of miR-342-5p is low and NSCs maintain the potential to differentiate into GFAP-positive astrocytes. When some NSCs gradually differentiate into I

• br Introduction Hematopoietic stem cells HSCs persist

  2018-11-05

  

  Introduction Hematopoietic stem n-acetyl-l-cysteine (HSCs) persist throughout life to produce hematopoietic progenitor cells (HPCs) and all types of blood cells. In the adult, HSCs reside in bone marrow (BM), are rare but have the unique capability for self-renewal and multilineage differentiati

• br Experimental Procedures br Author Contributions

  2018-11-05

  

  Experimental Procedures Author Contributions Acknowledgments This study was supported by the UCR Initial Complement Fund and the UCR Stem Cell Core Facility, funded by CIRM. Introduction Since the advent of cellular reprogramming with exogenous transcription factors (Takahashi et al., 2

• their mathematical expectations follow the

  2018-11-05

  

  their mathematical expectations follow the expressions According to the CLT for independent random variables , for N → ∞  the expression tends to a standardized Gaussian random variable. Therefore for N ≫ 1 we have the following approximate equalities: where θ0, , are the standardized Gaussian

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