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The host virus coexistence is completely dependent on the
2019-11-13
The host-virus coexistence is completely dependent on the balance between a strong immune response inhibiting virus replication and immune evasion and survival of the virus with periodic shedding to enable transmission to new hosts. In the process of ensuring this balance, the virus manipulates 7TM
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With respect to the muscle compartment only
2019-11-13
With respect to the muscle compartment, only low protein expression of ASB9 has been detected in healthy human skeletal muscle [as reported in the Human Protein Atlas (HPA)], whereas high levels of Asb5 protein expression are detected in mammalian skeletal muscle, which appears to be important in th
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The nuclear receptor related protein Nurr
2019-11-13
The nuclear receptor related-1 protein, Nurr1 (NR4A2), is a transcription factor that regulates the Outcome of genes critical for the development, maintenance, and survival of dopaminergic neurons (Alavian et al., 2014, Decressac et al., 2013, Dong et al., 2016, Jankovic et al., 2005, Johnson et al
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MdHCLB channels expressed in Xenopus oocytes produced
2019-11-13
MdHCLB channels expressed in Xenopus oocytes produced currents in response to HA and GABA (Fig. 1, Fig. 3). This is in agreement with the findings with Drosophila HCLB channels (Gisselmann et al., 2004). In the HA concentration-response curves, the effects of GABA were additive to those of HA only i
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We found that the postnatal absence of norepinephrine yields
2019-11-13
We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and TC-I 2000 region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocampus in Dbh−/−
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The notion that a small
2019-11-12
The notion that a small subset of inducible cellular transcripts, encoding immunological important factors, is translocated across the nuclear envelope by the karyopherin CRM1 is gaining support from various recent studies. For example, experimental evidence has been provided demonstrating that the
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Hinokitiol has versatile abilities as anticancer antimicrobi
2019-11-12
Hinokitiol has versatile abilities as anticancer, antimicrobial and molecule transport agents and appears to have no developmental toxicity or carcinogenic effects (Imai et al., 2006b). For anticancer activities, it causes apoptosis and kisspeptin arrest in many different types of cancers, such as m
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br Introduction Vein graft implantation into the
2019-11-12
Introduction Vein graft implantation into the arterial environment for surgical bypass is the gold standard to treat severe cardiovascular occlusive disease. After placement of a vein into the higher pressure, flow, and oxygen tension of the arterial circulation, the vein adapts to the arterial e
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tranylcypromine br Conflict of interest br Introduction Endo
2019-11-12
Conflict of interest Introduction Endothelin receptors are members of the superfamily of G-protein-coupled receptors (GPCRs) and central regulators of vascular tension and other physiological functions in higher eukaryotes [1]. The human endothelin system comprises the highly homologous endoth
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br Material and methods br Results br Discussion Isolated ce
2019-11-12
Material and methods Results Discussion Isolated biperiden have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore, they m
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Alpha SYN has no direct
2019-11-12
Alpha-SYN has no direct effect on forskolin-induced CREB phosphorylation, but rather blocks the stimulation of CRE-mediated transcription in the nucleus. Previously we suggested that α-SYN can enter the nucleus and is present in both cytosolic and nuclear fractions without direct interaction between
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Consistent with our previous study Gao
2019-11-12
Consistent with our previous study (Gao et al., 2018b; Wu et al., 2018), we found that TCB-2 disrupted both pup preference and home-cage maternal behavior. Based on the findings that 4-h pup ESI-09 (a technique presumably increases maternal motivation) failed to attenuate the TCB-2-induced maternal
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The data from drug screening
2019-11-12
The data from drug screening in P. berghei (Fig. 3D) provide proof of concept that chemogenomic profiling can be accomplished in P. berghei in the same manner as P. falciparum, in that significant increases in the EC50 ratio were found only for antifolate drugs in the parasite with attenuated TgDHFR
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br Materials and Methods br Results br Discussion HSCs
2019-11-12
Materials and Methods Results Discussion HSCs have been identified as major collagen-producing Linagliptin in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regulato
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The DDR mediated lysyl oxidase induction in osteoblasts repo
2019-11-12
The DDR2-mediated lysyl oxidase induction in osteoblasts reported here is a novel function for this receptor. Various functions have been reported for DDR2. In an in-vitro study, Zhang and colleagues showed that DDR2 activation leads to Runx2 phosphorylation, which regulates osteoblast differentiati
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