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Introduction The adult intestinal epithelium
2018-11-08
Introduction The adult intestinal epithelium is a self-renewing tissue with a high turnover rate maintained by intestinal stem cells that reside at the O4I1 of glands (called crypts). Lgr5 (leucine-rich-repeat-containing G protein-coupled receptor 5), a Wnt/β-catenin target gene, exclusively marks
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PARK is a ubiquitously expressed protein and
2018-11-08
PARK2 is a ubiquitously expressed protein, and its ubiquitination of outer mitochondrial membrane is a prerequisite step in mitophagy-mediated removal of damaged mitochondria. However, PARK2 abnormalities in Stattic cost other than neurons fail to display the selective loss of a particular populati
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br Material and methods br Results br Discussion CHI usually
2018-11-08
Material and methods Results Discussion CHI usually results in severe and permanent neurological impairment. However, there is no single effective therapy for neurological deficits (Kumar and Loane, 2012). Additionally, there is no single animal model reproducing the entire spectrum of neur
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Multi electrode array approaches have been proposed as a too
2018-11-08
Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure
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br Results br Discussion Analysis of DNA damage
2018-11-08
Results Discussion Analysis of DNA-damage foci in CHK1i-treated EMD638683 led to the remarkable discovery that CHK1i allowed FA-deficient iPSCs to escape G2 arrest and undergo mitosis without repairing the DSBs that had evidently caused their arrest. A previous study indicates that DSBs arisi
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The present study indicated that induction of glutamatergic
2018-11-08
The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced vG
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br Ethics approval br Acknowledgments br Introduction Low so
2018-11-07
Ethics approval Acknowledgments Introduction Low socioeconomic status (SES) is frequently found to be associated with poor health outcomes, despite substantial advances in prevention and treatment of disease (Phelan & Link, 2005; Braveman, Cubbin, Marchi, Egerter, & Chavez, 2001; Janssen, B
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Hence Hulme and Shepherd aware
2018-11-07
Hence, Hulme and Shepherd (2003), aware of the need to distinguish the different forms of poverty, define five groups, according to the location of poverty\'s punctual and average indicators vis-à-vis the poverty line. This paper seeks to adapt such typology to Brazil\'s case, using PME (Monthly Job
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The development of a malaria vaccine is considered
2018-11-07
The development of a malaria vaccine is considered as one of the most cost-effective measures to counter the disease. Valuable progress has been achieved in the last 30years in the development of subunit vaccines () that could be included in the Expanded Program of Immunization (EPI), whereas the
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Worry about the next night s
2018-11-07
Worry about the next night\'s insomnia was an important part of the routine. The finding suggests that in addition to the experience of insomnia, these patients worry about being an insomniac. The issue explains a state similar to anticipatory anxiety in panic disorders in which a patient experience
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br Conclusiones br Introducci n br I
2018-11-07
Conclusiones Introducción I. El entorno económico y financiero mundial El entorno monetario y financiero mundial se encuentra en un proceso continuo de transformación y ajuste. El cual es el producto de un entorno conflictivo de juego suma cero en el que un país gana lo que otro pierde, por
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Increasing globalization in travel and trade will intensify
2018-11-07
Increasing globalization in travel and trade will intensify the importation of dengue viruses and the potential for further introduction of Ae. aegypti (Gubler and Clark, 1995). If such introductions coincide with suitable vectorial capacity, those cities at the time intervals identified in this stu
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Interestingly SR had an anabolic effect
2018-11-07
Interestingly, SR10171 had an anabolic effect on the appendicular but not the axial skeleton, whereas rosiglitazone had a negative effect in both skeletal sites. There are several possible explanations for this divergence. Firstly, osteocytes were shown to be a major anabolic target of SR10171. Thes
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The endocannabinoid system ECS is a recently emerging comple
2018-11-07
The endocannabinoid system (ECS) is a recently emerging complex regulator of multiple physiological processes. It comprises several endogenous ligands (e.g. -arachidonoylethanolamine, a.k.a. anandamide [AEA], 2-arachidonoylglycerol [2-AG], palmitoylethanolamide [PEA], etc.), a number of endocannabin
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Similar to other solid tumors the characteristics such as
2018-11-07
Similar to other solid tumors, the characteristics such as tumor size, tumor differentiation, tumor node numbers, vascular invasion, and metastasis status are important prognosis factors for HCC patients (Noh et al., 2016). These characteristics constitute the tumor-node-metastasis (TNM) classificat
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