• Taken together our results demonstrate

  2019-10-12

  

  Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 would prevent some

• As for the molecular mechanism Ferguson BD suggested that

  2019-10-12

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of Taxifolin with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 expression levels

• Future advances in the in vivo molecular imaging of

  2019-10-12

  

  Future advances in the in vivo molecular imaging of enzyme activity will greatly benefit from the progress towards the quantitative detection of enzymes. Quantitative imaging requires knowledge of both the location and concentration of a specific enzyme, which is dependent on the simultaneous measur

• Introduction In vitro synthetic biology has received conside

  2019-10-12

  

  Introduction In vitro synthetic biology has received considerably less attention than in vivo processes so far (Foster and Church, 2007). However, cell-free biosynthetic production is very likely to become important for many biotechnological challenges for reasons such as (energy) efficiency, syste

• In general we observed that the enolase gene with highest

  2019-10-11

  

  In general, we observed that the enolase gene with highest mRNA levels was TVAG_043500, under all three iron concentration conditions. mRNA levels for this gene are very similar in normal and iron rich cultures (73.9 and 78.1 fold change, respectively), and higher in iron depleted cultures (118.3 fo

• We not only found that the

  2019-10-11

  

  We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is

• Our study found a significant association between the degree

  2019-10-11

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P Galanthamine status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between EGFR mutat

• A study profiling chemokine expression in LCLs revealed high

  2019-10-11

  

  A study profiling chemokine expression in LCLs revealed high expression levels of CCR6, CCR7, and CCR10 and low expression of CXCR4 and CXCR5 in EBV immortalized cells. Accordingly, LCLs showed a markedly increase in migration in response to the ligands of CCR6 (CCL20), CC7 (CCL21), and CCR10 (CCL28

• Terazosin clinical E ligases provide substrate recognition s

  2019-10-11

  

  E3 ligases provide substrate recognition specificity Ubiquitination Terazosin clinical and substrate specificity in mammals is achieved by the existence of over six-hundred E3-ubiquitin ligases that catalyze the final step of ubiquitination, compared with only one E1 and very few E2 enzymes known

• br Results br Discussion The ubiquitin system

  2019-10-11

  

  Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i

• br Effect of DPP Inhibitors on the Clinical

  2019-10-11

  

  Effect of DPP-4 Inhibitors on the Clinical Course of Heart Failure Four large-scale cardiovascular outcomes trials with DPP-4 inhibitors have been completed, and their findings have been published (Table 1) 31, 32, 33, 34. In 2 studies (with saxagliptin and alogliptin), DPP-4 inhibition was accom

• Thus DGK active sites remain ill

  2019-10-11

  

  Thus, DGK-active sites remain ill-defined and, combined with the lack of crystal structures for mammalian DGKs, have limited our understanding of substrate and inhibitor binding. As a result, current DGK inhibitors consist of compounds with poor specificity within the DGK superfamily (de Chaffoy de

• BPTES clinical br Cytokines and NK cells br Combined effects

  2019-10-11

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK BPTES clinical have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and eff

• Programmed cell death via apoptosis is

  2019-10-11

  

  Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap

• The ACC receptor family appear to

  2019-10-11

  

  The ACC receptor family appear to be attractive targets for the development of novel anthelmintics. With this in mind we also tested the activity of the anthelmintics levamisole and pyrantel which activate the nematode nAChR (Martin and Robertson, 2007). We found both molecules were partial agonists

16162 records 961/1078 page Previous Next First page 上5页 961962963964965 下5页 Last page