• The leaves of Bambusa nutans

  2024-12-04

  

  The leaves of Bambusa nutans, B. vulgaris, B. textilis McClure, B. vulgaris var. vittata, and Dendrocalamus oldhami are reported as promising natural alternatives to synthetic antioxidants as functional food ingredients (Tripathi et al., 2015). Luo et al. (2015), identified two novel flavonoids name

• The efficacy of antibiotics in

  2024-12-04

  

  The efficacy of Dehydrocostus Lactone in improving smell function has been previously found to be negative, both when used for bacterial and viral infections. Van Zele et al, in a double-blind, placebo-controlled, multicenter study, found no influence of doxycycline treatment on self-reported olfact

• br Introduction Sustained over activation of

  2024-12-04

  

  Introduction Sustained over-activation of neurohormonal systems is a hallmark in the pathophysiology of cardiac dysfunction following myocardial infarction (MI) and heart failure (HF). Inhibitors of the renin-angiotensin racecadotril mg system (RAAS) constitute cornerstones of pharmacotherapy fo

• br Conflict of interest br

  2024-12-02

  

  Conflict of interest Acknowledgement This study was supported by a grant from University Grants Commission - Basic Scientific Research (UGC-BSR), New Delhi, India (UGC-BSR No:F-7-115/2007). Introduction The G protein-coupled receptors activated by extracellular adenosine (Ado), called Aden

• Genetic observations from these studies suggest that

  2024-12-02

  

  Genetic observations from these studies suggest that GMF regulates Arp2/3 complex and cholecystokinin receptor dynamics in vivo13, 14. Budding yeast Gmf1 localizes to cortical actin patches, sites of endocytosis assembled by Arp2/3 13, 14. Furthermore, deletion of GMF1 exacerbates the growth defect

• br Introduction Fungi are an inexhaustible source of natural

  2024-12-02

  

  Introduction Fungi are an inexhaustible source of natural products mainly due to their wide distribution in the nature, estimated to range from 1.5 to 5.1 million species in the world [1]. Secondary metabolites from fungi represent a substantial fraction of drugs and drug models in pharmaceutical

• Toxicity is the main reason for the failure

  2024-12-02

  

  Toxicity is the main reason for the failure at all stages of the new drug development process. The major part of safety-related attrition occurs at preclinical phases while predicting preclinical safety liabilities earlier in the drug development process. This strategy enables the design and/or sele

• Finasteride has been shown to be a mechanism

  2024-12-02

  

  Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a

• The role of DHT in early teleost embryogenesis is

  2024-12-02

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

• br Materials and methods br Results To explore the potential

  2024-12-02

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the wst-1 of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression of p62 was revealed to

• Imatinib is a well known

  2024-12-02

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing Veliparib (K562 cell

• In this study significant reduction in the

  2024-12-02

  

  In this study, significant reduction in the HCO3− content in sham-operated and testosterone-treated rats following bafilomycin A1 administration suggested that V-ATPase could be involved in mediating the decrease in vas deferens fluid HCO3− content, most probably due to the increase in H+ secretion

• Demonstration of in vivo efficacy of potential

  2024-12-02

  

  Demonstration of in vivo efficacy of potential chemopreventive agents in animal models is necessary for their clinical development. Our present study provides experimental evidence that CuB 0.1μmol by oral administration (for 2weeks before the cancer cell injection, 5days per week) significantly inh

• and LO are members of the lipoxygenase family

  2024-12-02

  

  5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic AKT inhibitor VIII into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activatio

• The interaction of ATR ATRIP

  2024-12-02

  

  The interaction of ATR-ATRIP with RPA-coated ssDNA is sufficient for ATR-ATRIP recruitment to DNA lesions, but it is not sufficient to fully activate ATR. In response to DNA damage, the heterotrimeric ring-shaped complex 9-1-1 (RAD9-RAD1-HUS1 in humans; Ddc1-Rad17-Mec3 in S. cerevisiae) is loaded at

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