Whole exome sequencing of tumor

2018-10-20

Whole-exome sequencing of tumor DNA from GBM 5 identified a total of 32 SNVs (Table S3). A subset of these SNVs was selected for single-cell analysis based on putative gene function and variant allele fractions encompassing high, low, and intermediate frequencies. The genomic targets selected includ

Our data confirm previously unrecognized levels of temporal

2018-10-20

Our data confirm previously unrecognized levels of temporal diversity and complexity in the subclonal landscape of GBM. In all cases analyzed, genetically distinct subclones had variable serial repopulating activity in vivo. We can exclude the possibility that the presence of in vitro aberrations pl

Recently several clinical trials of stem cell

2018-10-20

Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et

br Funding This work was funded by NIHR GM

2018-10-20

Funding This work was funded by NIHR01GM085456 awarded to Tanja Dominko. Declaration of interest The following are the supplementary data related to this article. Acknowledgements Introduction The identification of culture conditions that promote the expansion of primitive hematopoieti

br Introduction Visional signals are

2018-10-20

Introduction Visional signals are mediated by photoreceptors, bipolar Radicicol and ganglion cells, and the loss of these neurons leads to irreversible blindness (de Jong, 2006; Friedman et al., 2004; Hartong et al., 2006; Quigley and Broman, 2006; Ramsden et al., 2013; Thylefors et al., 1995). P

Next we unraveled a mechanism by

2018-10-20

Next, we unraveled a mechanism by which exogenous ANXA3 proteins are internalized in HCC GSK1070916 and characterized the mechanism by which ANXA3 promotes CSC-like properties following its internalization. There has been no study regarding the route of entry of exogenous ANXA3 in any cell type thus

It is interesting that OB

2018-10-20

It is interesting that OB neurons produced from the transient Gli1-enriched subcallosal domain in juvenile mice mostly corresponded to sGCs, when they were derived from a region with active SHH signaling. It is possible that the relative levels of SHH signaling are adjusted in different domains. The

monocarboxylate transporters EWS FLI a widely recognized fus

2018-10-20

EWS-FLI1, a widely recognized fusion oncogene for Ewing sarcomas, is generated by the chromosomal translocation of t(11;22) (q24;q12), which consists of the N-terminal transactivator domain of the EWS gene and the C-terminal ETS DNA binding domain of the FLI1 gene. The resulting EWS-FLI1 fusion prot

Further analysis of subtype specification of hiNSCs

2018-10-20

Further analysis of subtype specification of hiNSCs indicated that after 2 weeks in culture, hiNSCs spontaneously differentiate into mostly glutamatergic and GABAergic neurons, and do not express high levels of the dopaminergic neuron marker TH. While these subtypes were obtained from spontaneous di

Hello world!

2018-07-29